Assay Detail
Functional
CHEMBL5258069
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against amastigote form of Leishmania donovani assessed as parasite growth inhibition
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Active Natural Product Scaffolds against Trypanosomatid Parasites: A Review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.90 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 8.40 |
| CHEMBL370143 | PAROMOMYCIN | 4.0 | 1 | 8.15 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.16 |
| CHEMBL5291279 | — | — | 1 | 5.72 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.55 |
| CHEMBL294009 | FLAVONOL | — | 1 | 5.52 |
| CHEMBL4166627 | — | — | 1 | 5.52 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.48 |
| CHEMBL5265760 | — | — | 1 | 4.99 |
| CHEMBL115585 | NEOCRYPTOLEPINE | — | 1 | 4.30 |
| CHEMBL307456 | SCEPTRIN | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290960 | NIFURTIMOX | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL370143 | PAROMOMYCIN | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL267345 | AMPHOTERICIN B | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5291279 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL151 | LUTEOLIN | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL294009 | FLAVONOL | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4166627 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL50 | QUERCETIN | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL5265760 | — | EC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL115585 | NEOCRYPTOLEPINE | EC50 | = | 49500.0 | nM | 4.30 |
| CHEMBL307456 | SCEPTRIN | EC50 | = | 83000.0 | nM | 4.08 |