Assay Detail
Functional
CHEMBL1019333
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Inhibition of protein translation in Escherichia coli by coupled transcription/translation assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.03 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6067485 | GENTAMICIN | 4.0 | 1 | 7.70 |
| CHEMBL370143 | PAROMOMYCIN | 4.0 | 1 | 7.25 |
| CHEMBL511656 | — | — | 1 | 6.80 |
| CHEMBL474967 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6067485 | GENTAMICIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL370143 | PAROMOMYCIN | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL511656 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL474967 | — | IC50 | = | 415.0 | nM | 6.38 |