Compound Detail
CHEMBL5315124
LEVOFLOXACIN 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23.C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23.O
21
Targets
57
Activities
2
Assay Types
30
PK Parameters
20
Publications
19
Known Names
20
Indications
2
Mechanisms
Molecular Properties
361.4
MW (Da)
1.54
ALogP
6
HBA
1
HBD
75.0
PSA (Ų)
0.87
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1996 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| DNA gyrase inhibitor | INHIBITOR | DNA gyrase | ✓ | ✓ |
| Topoisomerase IV inhibitor | INHIBITOR | Topoisomerase IV | ✓ | ✓ |
Indications
Bacterial Infections Bronchitis, Chronic Conjunctivitis, Bacterial Cystic Fibrosis Eye Infections Infections Pneumonia Respiratory Tract Infections Sinusitis Urinary Tract Infections Bronchitis Cataract Dyspepsia Endocarditis Fever Helicobacter Infections Hot Flashes Influenza, Human Maxillary Sinusitis Neutropenia
ATC Classification
J01MA12
levofloxacin
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
S01AE05
levofloxacin
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
Activity Summary
IC50 54 meas. best 6.9
EC50 3 meas. best 6.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Klebsiella pneumoniae CHEMBL350 | IC50 | 6.9 | 6.075 | 125.0 | 4 |
| Staphylococcus aureus CHEMBL352 | IC50 | 6.9 | 6.178 | 125.0 | 5 |
| Escherichia coli CHEMBL354 | IC50 | 6.9 | 5.8 | 125.0 | 3 |
| Staphylococcus epidermidis CHEMBL353 | IC50 | 6.6 | 6.2 | 250.0 | 3 |
| Unchecked CHEMBL612545 | IC50 | 6.43 | 6.295 | 370.0 | 2 |
| Mycobacterium tuberculosis CHEMBL360 | IC50 | 6.23 | 5.9567 | 590.0 | 6 |
| Streptococcus CHEMBL612313 | EC50 | 6.04 | 6.04 | 911.0 | 1 |
| Enterococcus faecalis CHEMBL362 | IC50 | 6.0 | 6.0 | 1000.0 | 3 |
| Streptokinase A CHEMBL1293228 | EC50 | 5.81 | 5.81 | 1546.0 | 1 |
| Streptococcus sp. 'group A' CHEMBL612389 | EC50 | 5.68 | 5.68 | 2103.0 | 1 |
| Replicase polyprotein 1ab CHEMBL4295557 | IC50 | 5.12 | 5.12 | 7600.0 | 1 |
| Tubulin CHEMBL2095182 | IC50 | 4.95 | 4.95 | 11270.0 | 1 |
| Multidrug and toxin extrusion protein 1 CHEMBL1743126 | IC50 | 4.75 | 4.75 | 17900.0 | 1 |
| MCF-10A CHEMBL614321 | IC50 | 4.6 | 4.6 | 25200.0 | 1 |
| DNA gyrase subunit A CHEMBL4165 | IC50 | 4.28 | 4.28 | 52000.0 | 1 |
| Enterococcus faecium CHEMBL357 | IC50 | 4.19 | 4.19 | 64000.0 | 3 |
| LoVo CHEMBL614721 | IC50 | 4.17 | 4.17 | 67000.0 | 2 |
| A549 CHEMBL392 | IC50 | 4.17 | 4.165 | 67000.0 | 2 |
| PC-3 CHEMBL390 | IC50 | 4.17 | 4.17 | 67000.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 4.17 | 4.17 | 67000.0 | 1 |
| MCF7 CHEMBL387 | IC50 | 4.17 | 4.17 | 67000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 10.2 | ug ml-1 | - |
| AUC | 6100.0 | ng.hr.mL-1 | Cavia porcellus |
| AUC | 49800.0 | ng.hr.mL-1 | Mus musculus |
| AUC | 64000.0 | ng.hr.mL-1 | Mus musculus |
| AUC | 4.1 | mg.hr/kg | Mus musculus |
| AUC | 4.1 | mg.hr/kg | Mus musculus |
| AUC | 112400.0 | ng.hr.mL-1 | Callithrix jacchus |
| AUC | 63600.0 | ng.hr.mL-1 | Callithrix jacchus |
| AUC | 81400.0 | ng.hr.mL-1 | Callithrix jacchus |
| AUC | 47.5 | ng.hr.mL-1 | Homo sapiens |
| AUC | 56.3 | ng.hr.mL-1 | Homo sapiens |
| AUC | 33.4 | ng.hr.mL-1 | Macaca mulatta |
| AUC | 21.3 | ng.hr.mL-1 | Macaca mulatta |
| AUC | 106000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 117000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 77000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 68000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 2500.0 | ng.hr.mL-1 | Mus musculus |
| AUC | 11000.0 | ng.hr.mL-1 | Mus musculus |
| AUC | 4000.0 | ng.hr.mL-1 | Mus musculus |
| AUC | - | - | Mus musculus |
| AUC | 15500.0 | ng.hr.mL-1 | Macaca fascicularis |
| AUC | 15200.0 | ng.hr.mL-1 | Macaca fascicularis |
| AUC | 19300.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 16400.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 5570.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 3410.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 27200.0 | ng.hr.mL-1 | Homo sapiens |
| AUC | 47900.0 | ng.hr.mL-1 | Homo sapiens |
| AUC | 48300.0 | ng.hr.mL-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL3885881 | Rattus norvegicus | 332 |
| 19364867 | 10.1128/aac.01252-08 | Clostridioides difficile | 83 |
| 17938189 | 10.1128/aac.01229-07 | Streptococcus pneumoniae | 77 |
| 19805554 | 10.1128/aac.00248-09 | Pseudomonas aeruginosa | 71 |
| 19188391 | 10.1128/aac.01133-08 | Escherichia coli | 64 |
| 21173174 | 10.1128/aac.00927-10 | Escherichia coli | 64 |
| 19307366 | 10.1128/aac.01531-08 | Streptococcus pneumoniae | 55 |
| 17876003 | 10.1128/aac.00827-07 | Streptococcus pneumoniae | 53 |
| 17043131 | 10.1128/aac.00600-06 | Salmonella typhimurium | 44 |
| 18591275 | 10.1128/aac.01684-07 | Acinetobacter baumannii | 40 |
| - | 10.1007/s00044-012-0429-8 | Staphylococcus aureus | 39 |
| 18725440 | 10.1128/aac.00082-08 | Streptococcus pneumoniae | 38 |
| 20308374 | 10.1128/aac.01797-09 | Streptococcus pneumoniae | 38 |
| 17145801 | 10.1128/aac.01033-06 | Burkholderia pseudomallei | 37 |
| 17908940 | 10.1128/aac.00971-07 | Streptococcus pneumoniae | 34 |
| 18490500 | 10.1128/aac.01686-07 | Escherichia coli | 33 |
| 17296740 | 10.1128/aac.00646-06 | Staphylococcus aureus | 30 |
| 19884376 | 10.1128/aac.01123-09 | Streptococcus pneumoniae | 30 |
| 17220419 | 10.1128/aac.00959-06 | Streptococcus pneumoniae | 30 |
| 18809945 | 10.1128/aac.00707-08 | Pseudomonas aeruginosa | 28 |
Data from ChEMBL 36 via Core Engine