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Assay Detail

CHEMBL906490

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Functional
Inhibition of protein synthesis in Escherichia coli by coupled transcription-translation assay
ChEMBL ↗
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Escherichia coli
Confidence 1 — Organism
Curated By Intermediate

Target

Escherichia coli (CHEMBL354) ↗
Type ORGANISM
Organism Escherichia coli

Publication

Synthesis and SAR of 3,5-diamino-piperidine derivatives: novel antibacterial translation inhibitors as aminoglycoside mimetics.
Zhou Y, Gregor VE, Ayida BK, Winters GC, Sun Z, Murphy D, Haley G, Bailey D, Froelich JM, Fish S, Webber SE, Hermann T, Wall D.
Bioorg Med Chem Lett (2007) 17 : 1206 -1210
PubMed 17188860 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 48 4.91 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1384 KANAMYCIN 4.0 1 6.40
CHEMBL396495 — — 1 6.00
CHEMBL441212 — — 1 6.00
CHEMBL130 CHLORAMPHENICOL 4.0 1 5.82
CHEMBL1440 TETRACYCLINE 4.0 1 5.55
CHEMBL387427 — — 1 5.52
CHEMBL231613 — — 1 5.30
CHEMBL374035 — — 1 5.16
CHEMBL231513 — — 1 5.16
CHEMBL218010 — — 1 5.16
CHEMBL398198 — — 1 5.10
CHEMBL397680 — — 1 5.10
CHEMBL398199 — — 1 5.10
CHEMBL231021 — — 1 5.00
CHEMBL449044 — — 1 5.00
CHEMBL396255 — — 1 5.00
CHEMBL219806 — — 1 5.00
CHEMBL231332 — — 1 4.96
CHEMBL398200 — — 1 4.96
CHEMBL415671 — — 1 4.92
CHEMBL388647 — — 1 4.89
CHEMBL396518 — — 1 4.89
CHEMBL230512 — — 1 4.85
CHEMBL397510 — — 1 4.82
CHEMBL230046 — — 1 4.80
CHEMBL388424 — — 1 4.77
CHEMBL388423 — — 1 4.77
CHEMBL230154 — — 1 4.75
CHEMBL231228 — — 1 4.72
CHEMBL230157 — — 1 4.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1384 KANAMYCIN IC50 = 400.0 nM 6.40
CHEMBL396495 — IC50 = 1000.0 nM 6.00
CHEMBL441212 — IC50 = 1000.0 nM 6.00
CHEMBL130 CHLORAMPHENICOL IC50 = 1500.0 nM 5.82
CHEMBL1440 TETRACYCLINE IC50 = 2800.0 nM 5.55
CHEMBL387427 — IC50 = 3000.0 nM 5.52
CHEMBL231613 — IC50 = 5000.0 nM 5.30
CHEMBL374035 — IC50 = 7000.0 nM 5.16
CHEMBL231513 — IC50 = 7000.0 nM 5.16
CHEMBL218010 — IC50 = 7000.0 nM 5.16
CHEMBL398198 — IC50 = 8000.0 nM 5.10
CHEMBL397680 — IC50 = 8000.0 nM 5.10
CHEMBL398199 — IC50 = 8000.0 nM 5.10
CHEMBL219806 — IC50 = 10000.0 nM 5.00
CHEMBL449044 — IC50 = 10000.0 nM 5.00
CHEMBL231021 — IC50 = 10000.0 nM 5.00
CHEMBL396255 — IC50 = 10000.0 nM 5.00
CHEMBL231332 — IC50 = 11000.0 nM 4.96
CHEMBL398200 — IC50 = 11000.0 nM 4.96
CHEMBL415671 — IC50 = 12000.0 nM 4.92
CHEMBL388647 — IC50 = 13000.0 nM 4.89
CHEMBL396518 — IC50 = 13000.0 nM 4.89
CHEMBL230512 — IC50 = 14000.0 nM 4.85
CHEMBL397510 — IC50 = 15000.0 nM 4.82
CHEMBL230046 — IC50 = 16000.0 nM 4.80
CHEMBL388423 — IC50 = 17000.0 nM 4.77
CHEMBL388424 — IC50 = 17000.0 nM 4.77
CHEMBL230154 — IC50 = 18000.0 nM 4.75
CHEMBL231228 — IC50 = 19000.0 nM 4.72
CHEMBL230157 — IC50 = 19000.0 nM 4.72
CHEMBL397748 — IC50 = 21000.0 nM 4.68
CHEMBL231231 — IC50 = 21000.0 nM 4.68
CHEMBL231330 — IC50 = 27000.0 nM 4.57
CHEMBL387798 — IC50 = 31000.0 nM 4.51
CHEMBL230917 — IC50 = 36000.0 nM 4.44
CHEMBL231229 — IC50 = 40000.0 nM 4.40
CHEMBL387586 — IC50 = 40000.0 nM 4.40
CHEMBL231331 — IC50 = 43000.0 nM 4.37
CHEMBL231230 — IC50 = 44000.0 nM 4.36
CHEMBL389084 — IC50 = 58000.0 nM 4.24
CHEMBL440968 — IC50 = 72000.0 nM 4.14
CHEMBL276220 — IC50 = 77000.0 nM 4.11
CHEMBL395260 — IC50 = 100000.0 nM 4.00
CHEMBL231022 — IC50 = 310000.0 nM -
CHEMBL398197 — IC50 = 800000.0 nM -
CHEMBL230045 — IC50 > 1000000.0 nM -
CHEMBL230513 — IC50 > 1000000.0 nM -
CHEMBL231187 — IC50 > 1000000.0 nM -