Assay Detail
Binding
CHEMBL3131237
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Inhibition of Escherichia coli FabH expressed in Escherichia coli BL21 (DE3) after 25 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.26 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3127229 | — | — | 1 | 5.68 |
| CHEMBL1384 | KANAMYCIN | 4.0 | 1 | 5.51 |
| CHEMBL3127243 | — | — | 1 | 5.47 |
| CHEMBL3127232 | — | — | 1 | 5.38 |
| CHEMBL3127233 | — | — | 1 | 5.36 |
| CHEMBL3127234 | — | — | 1 | 5.19 |
| CHEMBL3127238 | — | — | 1 | 4.99 |
| CHEMBL3127242 | — | — | 1 | 4.96 |
| CHEMBL3127226 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3127229 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1384 | KANAMYCIN | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3127243 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3127232 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3127233 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3127234 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3127238 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL3127242 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3127226 | — | IC50 | = | 16500.0 | nM | 4.78 |