Assay Detail
Functional
CHEMBL4033943
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Inhibition of protein translation in Escherichia coli S30 cell extract using circular DNA with pBESTluc after 60 mins
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.58 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1384 | KANAMYCIN | 4.0 | 1 | 7.52 |
| CHEMBL4074141 | — | — | 1 | 5.90 |
| CHEMBL4083503 | — | — | 1 | 5.66 |
| CHEMBL4065520 | — | — | 1 | 5.19 |
| CHEMBL4089761 | — | — | 1 | 5.09 |
| CHEMBL4081574 | — | — | 1 | 4.97 |
| CHEMBL4064500 | — | — | 1 | 4.72 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1384 | KANAMYCIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4074141 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4083503 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL4065520 | — | IC50 | = | 6460.0 | nM | 5.19 |
| CHEMBL4089761 | — | IC50 | = | 8140.0 | nM | 5.09 |
| CHEMBL4081574 | — | IC50 | = | 10690.0 | nM | 4.97 |
| CHEMBL4064500 | — | IC50 | = | 19180.0 | nM | 4.72 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | - | — | - |