Compound Detail
CHEMBL4083503
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NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](NC(=O)CCCc3cn(Cc4ccc(CN5CCN(c6cc7c(cc6F)c(=O)c(C(=O)O)cn7C6CC6)CC5)cc4)nn3)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O
Basic Information
| ChEMBL ID | CHEMBL4083503 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MYENMPCBZOWLRJ-RCHLUYSYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
1055.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Escherichia coli CHEMBL354 | IC50 | 5.66 | 5.66 | 2190.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Escherichia coli | IC50 | = | 2190.0 | nM | 5.66 | Inhibition of protein translation in Escherichia coli S30 cell extract using cir... | 28343755 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28343755 | 10.1016/j.bmc.2017.02.068 | Escherichia coli | 13 |
| 28343755 | 10.1016/j.bmc.2017.02.068 | Bacillus subtilis | 1 |
| 28343755 | 10.1016/j.bmc.2017.02.068 | Staphylococcus epidermidis | 1 |
Data from ChEMBL 36 via Core Engine