Assay Detail
Binding
CHEMBL1007541
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Inhibition of human recombinant squalene synthase expressed in Escherichia coli cells assessed as conversion of [3H]FPP to squalene by liquid scintillation
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.74 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL496801 | — | — | 1 | 6.52 |
| CHEMBL495624 | — | — | 1 | 6.28 |
| CHEMBL447414 | — | — | 1 | 6.28 |
| CHEMBL495623 | — | — | 1 | 6.13 |
| CHEMBL497618 | — | — | 1 | 6.00 |
| CHEMBL497634 | — | — | 1 | 5.96 |
| CHEMBL497616 | — | — | 1 | 5.80 |
| CHEMBL524084 | — | — | 1 | 5.21 |
| CHEMBL449115 | — | — | 1 | 4.70 |
| CHEMBL497617 | — | — | 1 | 4.52 |
| CHEMBL497635 | — | — | 1 | - |
| CHEMBL497815 | — | — | 1 | - |
| CHEMBL497410 | — | — | 1 | - |
| CHEMBL496802 | — | — | 1 | - |
| CHEMBL496803 | — | — | 1 | - |
| CHEMBL498628 | — | — | 1 | - |
| CHEMBL525377 | — | — | 1 | - |
| CHEMBL523897 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL496801 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL495624 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL447414 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL495623 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL497618 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL497634 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL497616 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL524084 | — | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL449115 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL497617 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL497635 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL497815 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL497410 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL496802 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL496803 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL498628 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL525377 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL523897 | — | Ki | > | 30000.0 | nM | - |