Assay Detail
Binding
CHEMBL1007650
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human factor 10a-catalyzed hydrolysis of S-2222
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.48 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382408 | PENTAGALLOYL GLUCOSE | — | 1 | 6.77 |
| CHEMBL510512 | TELLIMAGRANDIN II | — | 1 | 6.68 |
| CHEMBL488110 | — | — | 1 | 6.55 |
| CHEMBL506204 | PEDUNCULAGIN | — | 1 | 6.25 |
| CHEMBL509562 | CASUARIIN | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382408 | PENTAGALLOYL GLUCOSE | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL510512 | TELLIMAGRANDIN II | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL488110 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL506204 | PEDUNCULAGIN | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL509562 | CASUARIIN | IC50 | = | 720.0 | nM | 6.14 |