Coagulation factor X · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Coagulation factor X shows approved-linked disease relevance led by atrial fibrillation. 5 more disease programs remain visible in the same review block. 7 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P00742. Start with atrial fibrillation, then reuse UniProt P00742 as the stable protein anchor across project notes and exports.
Start with atrial fibrillation, then reuse UniProt P00742 as the stable protein anchor across project notes and exports.
Coagulation factor X shows approved-linked disease relevance led by atrial fibrillation. 5 more disease programs remain visible in the same review block. 7 linked drugs remain visible in the same block.
Start review with atrial fibrillation because it currently carries approved-linked support. Linked drugs include APIXABAN, BETRIXABAN, DAREXABAN, EDOXABAN TOSYLATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyCoagulation factor X
Review this target as Coagulation factor X, mapped to UniProt P00742. Sequence length is 488 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Coagulation factor X as ChEMBL target CHEMBL244, mapped to UniProt P00742. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Coagulation factor X is the right protein anchor across sources, using UniProt P00742 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why atrial fibrillation is currently framed as approved-linked support. It currently carries 7 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Coagulation factor X |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P00742 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Coagulation factor X |
| UniProt Accession | P00742 |
| Component Type | Protein |
| Sequence Length | 488 aa |
Coagulation factor X
Review this target as Coagulation factor X, mapped to UniProt P00742. Sequence length is 488 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Coagulation factor X shows approved-linked disease relevance led by atrial fibrillation. 5 more disease programs remain visible in the same review block.
Start review with atrial fibrillation because it currently carries approved-linked support. Linked drugs include APIXABAN, BETRIXABAN, DAREXABAN, EDOXABAN TOSYLATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL507020 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL152859 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL37251 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL174330 | 10.92 | Ki | 0.012 | Preclinical |
| CHEMBL387856 | 10.92 | Ki | 0.012 | Preclinical |
| CHEMBL226564 | 10.92 | Ki | 0.012 | Preclinical |
| CHEMBL270221 | 10.89 | Ki | 0.013 | Preclinical |
| CHEMBL352039 | 10.89 | Ki | 0.013 | Preclinical |
| CHEMBL402980 | 10.89 | Ki | 0.013 | Preclinical |
| CHEMBL152854 | 10.89 | Ki | 0.013 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 698 | 5,948 | 7.2 |
| cell-free format | 10 | 25 | 7.4 |
| organism-based format | 9 | 3 | 8.9 |
| cell-based format | 3 | 55 | 6.9 |
| assay format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-free format | 6 | 0 | — |
| assay format | 1 | 0 | — |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 5 | 19 | 5.8 |
| cell-based format | 2 | 14 | 5.0 |