Compound Detail

CHEMBL1201202

FONDAPARINUX

💊 Approved Drug

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💊 Approved Drug

CO[C@H]1O[C@H](COS(=O)(=O)O)[C@@H](O[C@@H]2O[C@@H](C(=O)O)[C@@H](O[C@H]3O[C@H](COS(=O)(=O)O)[C@@H](O[C@@H]4O[C@H](C(=O)O)[C@@H](O[C@H]5O[C@H](COS(=O)(=O)O)[C@@H](O)[C@H](O)[C@H]5NS(=O)(=O)O)[C@H](O)[C@H]4O)[C@H](OS(=O)(=O)O)[C@H]3NS(=O)(=O)O)[C@H](O)[C@H]2OS(=O)(=O)O)[C@H](O)[C@H]1NS(=O)(=O)O

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL1201202
Name	FONDAPARINUX
Phase	Approved
Structure Type	MOL
InChI Key	KANJSNBRCNMZMV-ABRZTLGGSA-N
Therapeutic	✓ Yes

Known Names

Fondaparinux ORG-31540 FREE ACID ORG31540 FREE ACID SR 901107A SR-901107A

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Molecular Properties

1508.3

MW (Da)

Drug Information

Molecule Type	Oligosaccharide
First Approval	2001
Availability	Prescription
Chirality	Single Enantiomer

Routes of Administration

Parenteral

Flags

Black Box Warning Natural Product

USAN Stem	-parinux
USAN Year	2001

Extended Properties

Molecular Formula	C31H53N3O49S8
MW	1508.27

Indications

Thrombosis Acute Coronary Syndrome Thromboembolism Venous Thromboembolism Venous Thrombosis Atrial Fibrillation Pneumonia, Viral Respiratory Insufficiency Severe Acute Respiratory Syndrome Thrombocytopenia Obesity, Morbid Ovarian Neoplasms Renal Insufficiency

ATC Classification

B01AX05

fondaparinux

Level 1: BLOOD AND BLOOD FORMING ORGANS

Level 2: ANTITHROMBOTIC AGENTS

Activity Summary

IC50 1 meas. best 7.96

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Coagulation factor X CHEMBL244	IC50	7.96	7.96	11.0	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Coagulation factor X	IC50	=	11.0	nM	7.96	Inhibition of coagulation factor 10a (unknown origin) incubated for 2 mins in pr...	32216347

Literature References

PubMed	DOI	Target Context	# Activities
32216347	10.1021/acs.jmedchem.0c00156	Coagulation factor X	1

Data from ChEMBL 36 via Core Engine