Assay Detail
Binding
CHEMBL1007710
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant LXRbeta expressed in Escherichia coli BL21 cells assessed as association of recombinant SRC1 to LXRbeta ligand binding domain by HTRF assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BL21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.80 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23296 | — | — | 1 | 7.80 |
| CHEMBL512490 | — | — | 1 | - |
| CHEMBL470040 | — | — | 1 | - |
| CHEMBL470041 | VIPERIDONE | — | 1 | - |
| CHEMBL486808 | — | — | 1 | - |
| CHEMBL487001 | ROSACEA ACID B | — | 1 | - |
| CHEMBL485990 | — | — | 1 | - |
| CHEMBL519222 | — | — | 1 | - |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | - |
| CHEMBL486197 | — | — | 1 | - |
| CHEMBL506838 | ACETYL PODOCARPIC ACID ANHYDRIDE | — | 1 | - |
| CHEMBL421115 | PODOCARIC ACID | — | 1 | - |
| CHEMBL194642 | — | — | 1 | - |
| CHEMBL521375 | — | — | 1 | - |
| CHEMBL422904 | 22(R)-HYDROXYCHOLESTEROL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23296 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL512490 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL470040 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL470041 | VIPERIDONE | EC50 | - | — | - | |
| CHEMBL486808 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL487001 | ROSACEA ACID B | EC50 | > | 50000.0 | nM | - |
| CHEMBL485990 | — | EC50 | - | — | - | |
| CHEMBL519222 | — | EC50 | - | — | - | |
| CHEMBL269277 | BETULINIC ACID | EC50 | > | 50000.0 | nM | - |
| CHEMBL486197 | — | EC50 | - | — | - | |
| CHEMBL506838 | ACETYL PODOCARPIC ACID ANHYDRIDE | EC50 | < | 3.0 | nM | - |
| CHEMBL421115 | PODOCARIC ACID | EC50 | > | 50000.0 | nM | - |
| CHEMBL194642 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL521375 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL422904 | 22(R)-HYDROXYCHOLESTEROL | EC50 | > | 15000.0 | nM | - |