Assay Detail
Functional
CHEMBL1007833
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Inhibition of TPA-induced ROS production in human neutrophils by chemiluminescence
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potential antipsoriatic avarol derivatives as antioxidants and inhibitors of PGE(2) generation and proliferation in the HaCaT cell line.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.68 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54909 | FRAXETIN | — | 1 | 6.00 |
| CHEMBL238756 | — | — | 1 | 5.60 |
| CHEMBL459814 | AVAROL | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54909 | FRAXETIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL238756 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL459814 | AVAROL | IC50 | = | 3600.0 | nM | 5.44 |