Assay Detail
Functional
CHEMBL1007863
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Antiviral activity against HIV1 replication in human C8166 cells by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Pestalofones A-E, bioactive cyclohexanone derivatives from the plant endophytic fungus Pestalotiopsis fici.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.08 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1735 | INDINAVIR SULFATE | 4.0 | 1 | 8.05 |
| CHEMBL522680 | PESTALOFONE B | — | 1 | 4.19 |
| CHEMBL522607 | PESTALOFONE A | — | 1 | 4.04 |
| CHEMBL443191 | PESTALOFONE E | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1735 | INDINAVIR SULFATE | EC50 | = | 8.81 | nM | 8.05 |
| CHEMBL522680 | PESTALOFONE B | EC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL522607 | PESTALOFONE A | EC50 | = | 90400.0 | nM | 4.04 |
| CHEMBL443191 | PESTALOFONE E | EC50 | = | 93700.0 | nM | 4.03 |