Assay Detail
Binding
CHEMBL1007986
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Inhibition of PGPH catalytic activity of 20S proteasome in human erythrocytes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Affinity labeling of the proteasome by a belactosin A derived inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.82 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64925 | MG-132 | — | 1 | 6.92 |
| CHEMBL498970 | — | — | 1 | 6.82 |
| CHEMBL491637 | — | — | 1 | 5.43 |
| CHEMBL490829 | — | — | 1 | 5.08 |
| CHEMBL491636 | BELACTOSIN A | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64925 | MG-132 | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL498970 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL491637 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL490829 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL491636 | BELACTOSIN A | IC50 | = | 14000.0 | nM | 4.85 |