Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL64925

MG-132
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL64925
Name MG-132
Phase Preclinical
Structure Type BOTH
InChI Key TZYWCYJVHRLUCT-VABKMULXSA-N
385
Targets
850
Activities
3
Assay Types
2
PK Parameters
20
Publications
0
Known Names

Molecular Properties

475.6
MW (Da)
3.59
ALogP
5
HBA
3
HBD
113.6
PSA (Ų)
0.36
QED
0
Ro5 Violations
14
Rot. Bonds

Drug Information

Molecule Type Protein
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C26H41N3O5
MW 475.63
Aromatic Rings 1
Heavy Atoms 34
NP-Likeness 0.18

Activity Summary

IC50 815 meas. best 9.82
Ki 30 meas. best 9.4
EC50 5 meas. best 6.83

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Procathepsin L
CHEMBL3837
 IC50 9.82 8.865 0.1 2
Unchecked
CHEMBL612545
 Ki 9.4 6.8329 0.4 7
Proteasome Macropain subunit
CHEMBL3492
 Ki 9.0 6.61 1.0 6
Proteasome Macropain subunit MB1
CHEMBL4662
 IC50 8.92 8.0688 1.2 8
Cathepsin K
CHEMBL268
 Ki 8.85 8.85 1.4 1
Proteasome Macropain subunit MB1
CHEMBL4662
 Ki 8.85 8.338 1.4 5
Unchecked
CHEMBL612545
 IC50 8.7 6.5804 2.0 26
Proteasome
CHEMBL612443
 Ki 8.4 8.4 4.0 2
Cathepsin B
CHEMBL4072
 Ki 7.92 7.28 12.0 2
ES6
CHEMBL2366373
 IC50 7.88 7.18 13.1 2
A101D
CHEMBL2366306
 IC50 7.48 7.0 32.8 2
Plasmodium falciparum
CHEMBL364
 IC50 7.46 7.46 35.0 1
OCUB-M
CHEMBL2366121
 IC50 7.43 6.12 37.4 2
LB2518-MEL
CHEMBL2366335
 IC50 7.42 5.99 37.6 2
SH-4
CHEMBL2366309
 IC50 7.37 6.795 43.1 2
Proteasome component C5
CHEMBL4208
 IC50 7.36 6.5933 44.0 6
KNS-42
CHEMBL2366261
 IC50 7.35 5.96 44.4 2
DSH1
CHEMBL2366079
 IC50 7.28 6.7 52.9 2
Proteasome Macropain subunit
CHEMBL3492
 IC50 7.28 6.014 52.0 5
NTERA-2-cl-D1
CHEMBL614206
 IC50 7.24 6.805 57.7 2
D-542MG
CHEMBL2366208
 IC50 7.22 7.22 59.6 1
KS-1
CHEMBL2366228
 IC50 7.19 6.6 64.6 2
20S proteasome
CHEMBL3831201
 IC50 7.17 6.1233 68.0 3
BL-41
CHEMBL2366173
 IC50 7.16 6.415 69.5 2
LXF-289 cell line
CHEMBL614107
 IC50 7.15 6.21 70.7 2
MMAC-SF
CHEMBL2366196
 IC50 7.14 6.315 72.7 2
D-247MG
CHEMBL2366237
 IC50 7.14 5.88 72.1 2
CP66-MEL
CHEMBL2366363
 IC50 7.12 6.6 75.0 2
NON-PROTEIN TARGET
CHEMBL3879801
 IC50 7.11 6.53 77.0 5
RAW264.7
CHEMBL612557
 IC50 7.1 6.6882 80.0 17
LB771-HNC
CHEMBL2366099
 IC50 7.09 6.53 80.4 2
no-10
CHEMBL2366071
 IC50 7.05 6.635 89.1 2
A388
CHEMBL2366355
 IC50 7.04 6.2 90.7 2
OPM-2
CHEMBL2366353
 IC50 6.98 6.55 104.7 2
OVCAR-4
CHEMBL614051
 IC50 6.96 5.715 109.4 2
HOP-62
CHEMBL614643
 IC50 6.96 5.695 109.5 2
MFH-ino
CHEMBL2366262
 IC50 6.95 6.44 111.1 2
ML-2
CHEMBL614356
 IC50 6.93 6.63 118.1 2
NEC8
CHEMBL2366340
 IC50 6.92 5.605 120.0 2
UACC-257
CHEMBL612796
 IC50 6.92 6.13 119.3 2
ONS-76
CHEMBL2366068
 IC50 6.89 6.47 129.3 2
MCF7
CHEMBL387
 IC50 6.89 6.705 130.0 2
Proteasome component C5
CHEMBL4208
 Ki 6.89 5.7817 130.0 6
KE-37
CHEMBL2366287
 IC50 6.88 6.535 132.8 2
HT-144
CHEMBL2366291
 IC50 6.86 6.67 138.9 2
LB2241-RCC
CHEMBL2366330
 IC50 6.85 6.455 142.5 2
TE-5
CHEMBL2366245
 IC50 6.84 6.29 142.8 2
KINGS-1
CHEMBL2366229
 IC50 6.83 6.515 147.9 2
SARS-CoV-2
CHEMBL4303835
 EC50 6.83 6.7267 147.2 3
NCI-H69
CHEMBL614805
 IC50 6.82 5.94 151.4 2

Pharmacokinetic Data

Parameter Value Units Species
T1/2 2.0 hr Homo sapiens
T1/2 24.0 hr Homo sapiens

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Procathepsin L IC50 = 0.15 nM 9.82 Inhibition of Cathepsin L (unknown origin) preincubated for 30 mins followed by ... 36169610
Unchecked Ki = 0.4 nM 9.4 Inhibition of 20S proteasome from human erythrocyte 20112914
Proteasome Macropain subunit Ki = 1.0 nM 9.0 Inhibition of 20s immunoproteasome beta2 trypsin-like activity in human spleen u... 29292224
Proteasome Macropain subunit Ki = 1.0 nM 9.0 Inhibition of 20S immuno proteosome beta2i subunit (unknown origin) assessed as ... 34838650
Proteasome Macropain subunit MB1 IC50 = 1.2 nM 8.92 Inhibition of chymotrypsin like activity of 26S proteasome beta 5 subunit (unkno... 30581047
Proteasome Macropain subunit MB1 IC50 = 1.2 nM 8.92 Inhibition of beta5 proteasome (unknown origin) 33656892
Proteasome Macropain subunit MB1 Ki = 1.4 nM 8.85 Competitive inhibition of chymotrypsin-like activity of human 20S proteasome usi... 27318981
Proteasome Macropain subunit MB1 Ki = 1.4 nM 8.85 Inhibition of 20S constitutive proteosome beta5c subunit (unknown origin) assess... 34838650
Cathepsin K Ki = 1.4 nM 8.85 The apparent binding affinity against cathepsin K. 10669559
Unchecked IC50 = 2.0 nM 8.7 Inhibition of chymotrypsin like 20S proteasome activity in lymphoblastoid cells 17996987
Unchecked IC50 = 2.0 nM 8.7 Inhibition of chymotrypsin-like activity of 20S proteasome 18294845
Unchecked IC50 = 2.0 nM 8.7 Inhibition of chymotrypsin trypsin-like activity of proteasome from human LCL af... 19577931
Unchecked IC50 = 2.0 nM 8.7 Inhibition of chymotrypsin-like activity of 20S proteasome beta2 in human LCL ce... 20687609
Proteasome Macropain subunit MB1 Ki = 3.7 nM 8.43 Inhibition of chymotrypsin-like proteasome activity of human 20S proteasome 16686537
Proteasome Macropain subunit MB1 Ki = 4.0 nM 8.4 Inhibition of 20s constitutive proteasome beta5 chymotrypsin-like activity in hu... 29292224
Proteasome Ki = 4.0 nM 8.4 Inhibitory constant for the inactivation of the chymotrypsin like activity of pr... 9871688
Proteasome Ki = 4.0 nM 8.4 Inhibitory activity against 20S Proteasome 9871680
Unchecked IC50 = 5.0 nM 8.3 Inhibition of chymotrypsin-like activity of 20S proteasome beta 5 subunit by flu... 19250821
Proteasome Macropain subunit MB1 IC50 = 7.0 nM 8.15 Inhibition of 20S proteosome beta 5 purified from human HCT116 cells using Suc-L... 31312413
Proteasome Macropain subunit MB1 IC50 = 9.0 nM 8.05 Inhibition of chymotrypsin-like activity of proteasome beta-5 subunit in HEK293 ... 23540790

Literature References

PubMed DOI Target Context # Activities
20112914 10.1021/jm901619n Unchecked 31
26985310 10.1021/acsmedchemlett.5b00401 Unchecked 15
21888390 10.1021/jm200285z Unchecked 9
- 10.6019/CHEMBL4495565 SARS-CoV-2 8
19577931 10.1016/j.bmc.2009.06.025 Unchecked 6
16680159 10.1038/nchembio790 Unchecked 5
23506486 10.1021/jm3017199 Unchecked 4
- 10.6019/CHEMBL4495565 ADMET 4
- 10.6019/CHEMBL4495565 Vero C1008 4
30581047 10.1016/j.bmc.2018.12.022 Unchecked 3
18294845 10.1016/j.bmcl.2008.02.016 Unchecked 3
18024113 10.1016/j.bmcl.2007.10.100 NF-kappa-B inhibitor alpha 3
17511440 10.1021/jm0701324 Unchecked 3
18598018 10.1021/jm800194k Unchecked 3
30830772 10.1021/acs.jmedchem.9b00144 Proteasome 3
18801655 10.1016/j.bmcl.2008.08.073 Unchecked 3
20687609 10.1021/jm100122e Unchecked 3
19250821 10.1016/j.bmcl.2009.02.046 Unchecked 3
15780623 10.1016/j.bmcl.2005.02.013 20S proteasome 3
19428245 10.1016/j.bmcl.2009.04.103 Unchecked 3

Data from ChEMBL 36 via Core Engine