Assay Detail
Binding
CHEMBL5223569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of beta5 proteasome (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Proteases and Their Modulators in Cancer Therapy: Challenges and Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.44 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64925 | MG-132 | — | 1 | 8.92 |
| CHEMBL270515 | DELANZOMIB | 2.0 | 1 | 8.82 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.62 |
| CHEMBL5283576 | — | — | 1 | 8.59 |
| CHEMBL2103884 | OPROZOMIB | 2.0 | 1 | 8.52 |
| CHEMBL2141296 | IXAZOMIB | 3.0 | 1 | 8.47 |
| CHEMBL451887 | CARFILZOMIB | 4.0 | 1 | 8.22 |
| CHEMBL5269437 | — | — | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64925 | MG-132 | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL270515 | DELANZOMIB | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5283576 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2103884 | OPROZOMIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2141296 | IXAZOMIB | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL451887 | CARFILZOMIB | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5269437 | — | IC50 | = | 47.0 | nM | 7.33 |