Compound Detail
CHEMBL5283576
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Basic Information
| ChEMBL ID | CHEMBL5283576 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OLSLVDNVMYYZGX-CAMXFFFOSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
299.8
MW (Da)
0.74
ALogP
4
HBA
2
HBD
75.6
PSA (Ų)
0.46
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proteasome Macropain subunit MB1 CHEMBL4662 | IC50 | 8.59 | 8.59 | 2.6 | 1 |
| Proteasome Macropain subunit CHEMBL3492 | IC50 | 8.1 | 8.1 | 8.0 | 1 |
| Proteasome component C5 CHEMBL4208 | IC50 | 7.49 | 7.49 | 32.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proteasome Macropain subunit MB1 | IC50 | = | 2.6 | nM | 8.59 | Inhibition of beta5 proteasome (unknown origin) | 33656892 |
| Proteasome Macropain subunit | IC50 | = | 8.0 | nM | 8.1 | Inhibition of beta2 proteasome (unknown origin) | 33656892 |
| Proteasome component C5 | IC50 | = | 32.7 | nM | 7.49 | Inhibition of beta 1 proteasome (unknown origin) | 33656892 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33656892 | 10.1021/acs.jmedchem.0c01640 | Proteasome component C5 | 1 |
| 33656892 | 10.1021/acs.jmedchem.0c01640 | Proteasome Macropain subunit | 1 |
| 33656892 | 10.1021/acs.jmedchem.0c01640 | Proteasome Macropain subunit MB1 | 1 |
Data from ChEMBL 36 via Core Engine