Assay Detail
Binding
CHEMBL5223568
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Inhibition of beta2 proteasome (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Proteases and Their Modulators in Cancer Therapy: Challenges and Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.18 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5283576 | — | — | 1 | 8.10 |
| CHEMBL64925 | MG-132 | — | 1 | 5.97 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 5.92 |
| CHEMBL2141296 | IXAZOMIB | 3.0 | 1 | 5.46 |
| CHEMBL451887 | CARFILZOMIB | 4.0 | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5283576 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL64925 | MG-132 | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2141296 | IXAZOMIB | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL451887 | CARFILZOMIB | IC50 | = | 3600.0 | nM | 5.44 |