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Assay Detail

CHEMBL5144651

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of 20S immuno proteosome beta2i subunit (unknown origin) assessed as substrate hydrolysis using Z-Leu-Leu-Leu-al as substrate
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Proteasome Macropain subunit (CHEMBL3492)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of isoquinolinone derivatives as immunoproteasome inhibitors.
Ettari R, Iraci N, Di Chio C, Previti S, Danzè M, Zappalà M.
Bioorg Med Chem Lett (2022) 55 : 128478 -128478
PubMed 34838650 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.00 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL64925 MG-132 1 9.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL64925 MG-132 Ki = 1.0 nM 9.00