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Target Snapshot

CHEMBL2366373 Target Snapshot

ES6 · CELL-LINE · Homo sapiens

135Compounds
1Assays
30Approved Drugs
137.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats ES6 as ChEMBL target CHEMBL2366373. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
ES6
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366373
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether ES6 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelES6
UniProt AccessionN/A

ES6

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as ES6.

Review nameES6
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

30
Approved
12
Phase III
13
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC50137.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL96926 9.85 IC50 0.1401 Preclinical
CHEMBL888 9.23 IC50 0.5856 Approved
CHEMBL413 8.46 IC50 3.428 Approved
CHEMBL514499 8.21 IC50 6.193 Preclinical
CHEMBL300389 8.06 IC50 8.777 Preclinical
CHEMBL1256459 7.96 IC50 10.83 Preclinical
CHEMBL94657 7.95 IC50 11.24 Clinical
CHEMBL252164 7.9 IC50 12.61 Clinical
CHEMBL64925 7.88 IC50 13.06 Preclinical
CHEMBL3545252 7.7 IC50 20.08 Approved
Distribution

pChEMBL Value Distribution

16
5.0
8
5.5
14
6.0
7
6.5
6
7.0
7
7.5
3
8.0
0
8.5
1
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

PONATINIB
CHEMBL1171837
Approved 2012
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
DASATINIB
CHEMBL5416410
Approved 2006
SUNITINIB
CHEMBL535
Approved 2006
SIROLIMUS
CHEMBL413
Approved 1999
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
CYTARABINE
CHEMBL803
Approved 1969
VINBLASTINE
CHEMBL159
Approved 1965
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

1
Total Assays
135
Tested Compounds
1
Assay Types
Functional — 1 assays, 135 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 135 5.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine