Assay Detail
Binding
CHEMBL4311828
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Inhibition of chymotrypsin like activity of 26S proteasome beta 5 subunit (unknown origin) by fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tripeptide analogues of MG132 as protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.00 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64925 | MG-132 | — | 1 | 8.92 |
| CHEMBL4590466 | — | — | 1 | 6.86 |
| CHEMBL4574306 | — | — | 1 | 6.72 |
| CHEMBL4475662 | — | — | 1 | 6.66 |
| CHEMBL4531762 | — | — | 1 | 6.57 |
| CHEMBL4540394 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64925 | MG-132 | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4590466 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL4574306 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL4475662 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4531762 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL4540394 | — | IC50 | = | 514.0 | nM | 6.29 |