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Target Snapshot

CHEMBL614805 Target Snapshot

NCI-H69 · CELL-LINE · Homo sapiens

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410Compounds
114Assays
32Approved Drugs
528.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NCI-H69 as ChEMBL target CHEMBL614805. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NCI-H69
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614805
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NCI-H69 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNCI-H69
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNCI-H69
UniProt AccessionN/A

NCI-H69

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NCI-H69.

Review nameNCI-H69
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

32
Approved
13
Phase III
10
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50507.0
EC5021.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL39541 10.49 IC50 0.032 Clinical
CHEMBL4167069 9.2 IC50 0.63 Preclinical
CHEMBL162885 9.19 IC50 0.64 Preclinical
CHEMBL3688339 9.1 IC50 0.8 Preclinical
CHEMBL117142 9.06 IC50 0.87 Preclinical
CHEMBL162739 9.04 IC50 0.92 Preclinical
CHEMBL353127 9.02 IC50 0.95 Preclinical
CHEMBL4175749 9.0 IC50 1.01 Preclinical
CHEMBL65 9.0 IC50 1.0 Preclinical
CHEMBL350147 8.98 IC50 1.05 Preclinical
Distribution

pChEMBL Value Distribution

39
5.0
53
5.5
64
6.0
82
6.5
52
7.0
42
7.5
7
8.0
24
8.5
8
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

AFATINIB
CHEMBL1173655
Approved 2013
Properties Compare Identifier
VORINOSTAT
CHEMBL98
Approved 2006
Properties Compare Identifier
TOPOTECAN
CHEMBL84
Approved 1996
Properties Compare Identifier
IRINOTECAN
CHEMBL481
Approved 1996
Properties Compare Identifier
GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
DAUNORUBICIN
CHEMBL178
Approved 1979
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

114
Total Assays
337
Tested Compounds
2
Assay Types
Functional — 112 assays, 337 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 99 335 6.4
organism-based format 13 2 6.2
ADME — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine