Assay Detail
Binding
CHEMBL768298
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Inhibitory constant for the inactivation of the chymotrypsin like activity of proteasome from human red blood corpuscles was determined
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 2 — Organism |
| Curated By | Intermediate |
Publication
Inhibitors of the chymotrypsin-like activity of proteasome based on di- and tri-peptidyl alpha-keto aldehydes (glyoxals).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.76 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339658 | — | — | 1 | 8.51 |
| CHEMBL125034 | — | — | 1 | 8.43 |
| CHEMBL64925 | MG-132 | — | 1 | 8.40 |
| CHEMBL127764 | — | — | 1 | 5.85 |
| CHEMBL124146 | — | — | 1 | 5.69 |
| CHEMBL122379 | — | — | 1 | 5.41 |
| CHEMBL421464 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339658 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL125034 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL64925 | MG-132 | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL127764 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL124146 | — | Ki | = | 2050.0 | nM | 5.69 |
| CHEMBL122379 | — | Ki | = | 3860.0 | nM | 5.41 |
| CHEMBL421464 | — | Ki | = | 9200.0 | nM | 5.04 |