Assay Detail
Binding
CHEMBL1008046
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Small conductance calcium-activated potassium channel protein 3 (CHEMBL3780) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.34 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420873 | — | — | 1 | 8.85 |
| CHEMBL117908 | — | — | 1 | 8.74 |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | 4.0 | 1 | 6.85 |
| CHEMBL215370 | LAUDANOSINE METHIODIDE | — | 1 | 5.82 |
| CHEMBL558625 | — | — | 1 | 5.36 |
| CHEMBL1360 | ATRACURIUM | 4.0 | 1 | 5.23 |
| CHEMBL1687 | — | — | 1 | 5.04 |
| CHEMBL554917 | PENUCURONIUM | — | 1 | 4.80 |
| CHEMBL452887 | — | — | 1 | - |
| CHEMBL499968 | — | — | 1 | - |
| CHEMBL453730 | — | — | 1 | - |
| CHEMBL510780 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420873 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL117908 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL215370 | LAUDANOSINE METHIODIDE | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL558625 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL1360 | ATRACURIUM | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL1687 | — | Ki | = | 9200.0 | nM | 5.04 |
| CHEMBL554917 | PENUCURONIUM | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL452887 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL499968 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL453730 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL510780 | — | Ki | > | 50000.0 | nM | - |