Assay Detail
Functional
CHEMBL1008205
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of factor 10a in plasma of po dosed Wistar rat
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Stereoselective synthesis and biological evaluation of 3,4-diaminocyclohexanecarboxylic acid derivatives as factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.00 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479863 | — | — | 1 | 8.29 |
| CHEMBL538657 | — | — | 1 | 8.12 |
| CHEMBL245678 | — | — | 1 | 7.80 |
| CHEMBL501183 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479863 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL538657 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL245678 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL501183 | — | IC50 | = | 16.0 | nM | 7.80 |