Assay Detail
Functional
CHEMBL1008289
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Immunostimulatory activity in human Vgamma9/Vdelta2 T cells assessed as TNFalpha production after 12 hrs by ELISA
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thiopyrophosphoantigens: solid-phase synthesis and in vitro characterization of a new class of Vgamma9 Vdelta2 T cells activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 5.59 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL496034 | — | — | 1 | 8.32 |
| CHEMBL487584 | — | — | 1 | 7.26 |
| CHEMBL496219 | — | — | 1 | 7.25 |
| CHEMBL496406 | — | — | 1 | 6.41 |
| CHEMBL496418 | — | — | 1 | 6.00 |
| CHEMBL449238 | — | — | 1 | 5.43 |
| CHEMBL356362 | ISOPENTENYLPYROPHOSPHATE | — | 1 | 5.23 |
| CHEMBL509691 | — | — | 1 | 5.20 |
| CHEMBL496220 | — | — | 1 | 4.97 |
| CHEMBL492407 | — | — | 1 | 4.92 |
| CHEMBL489141 | — | — | 1 | 4.85 |
| CHEMBL495823 | — | — | 1 | 4.26 |
| CHEMBL495822 | — | — | 1 | 4.12 |
| CHEMBL496405 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL496034 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL487584 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL496219 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL496406 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL496418 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL449238 | — | EC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL356362 | ISOPENTENYLPYROPHOSPHATE | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL509691 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL496220 | — | EC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL492407 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL489141 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL495823 | — | EC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL495822 | — | EC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL496405 | — | EC50 | = | 100000.0 | nM | 4.00 |