Assay Detail
Functional
CHEMBL1008313
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-induced TNFalpha production in human whole blood preincubated for 1 hrs before LPS challenge measured after 4 hrs by ELISA
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and activity of quinolinylmethyl P1' alpha-sulfone piperidine hydroxamate inhibitors of TACE.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.32 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495831 | — | — | 1 | 5.89 |
| CHEMBL498032 | — | — | 1 | 5.82 |
| CHEMBL503067 | — | — | 1 | 5.72 |
| CHEMBL495621 | — | — | 1 | 5.62 |
| CHEMBL495795 | — | — | 1 | 5.62 |
| CHEMBL212481 | — | — | 1 | 5.60 |
| CHEMBL497012 | — | — | 1 | 5.60 |
| CHEMBL496619 | — | — | 1 | 5.55 |
| CHEMBL380049 | — | — | 1 | 5.06 |
| CHEMBL524533 | — | — | 1 | 4.96 |
| CHEMBL496423 | — | — | 1 | 4.85 |
| CHEMBL236572 | — | — | 1 | 4.85 |
| CHEMBL497838 | — | — | 1 | 4.85 |
| CHEMBL502796 | — | — | 1 | 4.55 |
| CHEMBL499854 | — | — | 1 | - |
| CHEMBL499313 | — | — | 1 | - |
| CHEMBL447275 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495831 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL498032 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL503067 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL495621 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL495795 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL212481 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL497012 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL496619 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL380049 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL524533 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL496423 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL236572 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL497838 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL502796 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL499854 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL499313 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL447275 | — | IC50 | > | 50000.0 | nM | - |