Assay Detail
Binding
CHEMBL1008336
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Displacement of [125I]PYY from rat NPY Y5 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.94 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522388 | — | — | 1 | 9.17 |
| CHEMBL524085 | — | — | 1 | 8.89 |
| CHEMBL491930 | — | — | 1 | 8.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522388 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL524085 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL491930 | — | IC50 | = | 1.7 | nM | 8.77 |