Assay Detail
Binding
CHEMBL1008496
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Inhibition of COX1
52
Total Activities
52
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Expanding the ChemGPS chemical space with natural products.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 4.82 | 8.00 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 8.00 |
| CHEMBL243796 | KURARINONE | — | 1 | 6.22 |
| CHEMBL243362 | KURAIDIN | — | 1 | 6.22 |
| CHEMBL260553 | — | — | 1 | 6.10 |
| CHEMBL456310 | — | — | 1 | 5.89 |
| CHEMBL108299 | EUGENYL ACETATE | — | 1 | 5.52 |
| CHEMBL450070 | ATRACTYLOCHROMENE | — | 1 | 5.48 |
| CHEMBL485460 | — | — | 1 | 5.48 |
| CHEMBL517609 | GLUTINONE | — | 1 | 5.44 |
| CHEMBL294199 | CAPSAICIN | 4.0 | 1 | 5.42 |
| CHEMBL281202 | CARVACROL | 2.0 | 1 | 5.40 |
| CHEMBL85139 | RUTAECARPINE | — | 1 | 5.06 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.06 |
| CHEMBL458470 | — | — | 1 | 5.00 |
| CHEMBL42710 | EUGENOL | 0.5 | 1 | 4.96 |
| CHEMBL465620 | — | — | 1 | 4.92 |
| CHEMBL267476 | LINOLEIC ACID | 2.0 | 1 | 4.89 |
| CHEMBL485981 | BUDDLEDIN A | — | 1 | 4.85 |
| CHEMBL159303 | EPIAFZELECHIN (2R,3R)(-) | — | 1 | 4.82 |
| CHEMBL464792 | TRANSCROCETIN | 3.0 | 1 | 4.55 |
| CHEMBL463770 | AKENDO 3 | — | 1 | 4.47 |
| CHEMBL250872 | SYRINGIN | — | 1 | 4.44 |
| CHEMBL456092 | KUTDTRIOL | — | 1 | 4.41 |
| CHEMBL465001 | GNAPHALIN | — | 1 | 4.40 |
| CHEMBL507430 | SANGGENON B | — | 1 | 4.38 |
| CHEMBL513113 | LUCINONE | — | 1 | 4.37 |
| CHEMBL458707 | — | — | 1 | 4.30 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 1 | 4.24 |
| CHEMBL244743 | ESCULETIN | — | 1 | 4.24 |
| CHEMBL464610 | SANGGENON D | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL243796 | KURARINONE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL243362 | KURAIDIN | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL260553 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL456310 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL108299 | EUGENYL ACETATE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL450070 | ATRACTYLOCHROMENE | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL485460 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL517609 | GLUTINONE | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL294199 | CAPSAICIN | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL281202 | CARVACROL | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL85139 | RUTAECARPINE | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL140 | CURCUMIN | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL458470 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL42710 | EUGENOL | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL465620 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL267476 | LINOLEIC ACID | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL485981 | BUDDLEDIN A | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL159303 | EPIAFZELECHIN (2R,3R)(-) | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL464792 | TRANSCROCETIN | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL463770 | AKENDO 3 | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL250872 | SYRINGIN | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL456092 | KUTDTRIOL | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL465001 | GNAPHALIN | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL507430 | SANGGENON B | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL513113 | LUCINONE | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL458707 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL244743 | ESCULETIN | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL464610 | SANGGENON D | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL518543 | KUWANON C | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL442564 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL350475 | OSTHENOL | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL69018 | FALCARINDIOL | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL464793 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL465208 | SALIDROSIDE | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL459056 | CONIFERIN | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL44 | GENISTEIN | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL311498 | CIANIDANOL | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL510672 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL125743 | GALLOCATECHIN | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL464006 | MORUSIN | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 380000.0 | nM | - |
| CHEMBL404515 | CYANIDIN | IC50 | = | 90000000.0 | nM | - |
| CHEMBL503797 | OURATEAPROANTHOCYANIDIN A | IC50 | = | 138000.0 | nM | - |
| CHEMBL462767 | PHILLYRIN | IC50 | = | 46.0 | % | - |
| CHEMBL165 | RESVERATROL | Activity | - | — | - | |
| CHEMBL449150 | BALLOTETROSIDE | IC50 | = | 1000000.0 | nM | - |
| CHEMBL244948 | DAPHNETIN | IC50 | = | 140000.0 | nM | - |
| CHEMBL465371 | KAZINOL B | IC50 | > | 100000.0 | nM | - |