Assay Detail
Binding
CHEMBL1008660
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Anti-estrogen binding site (AEBS) (CHEMBL612409) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Activity-guided isolation of steroidal alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.66 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL342394 | — | — | 1 | 6.40 |
| CHEMBL464782 | (+)-PACHYSAMINE B | — | 1 | 6.22 |
| CHEMBL455316 | — | — | 1 | 6.22 |
| CHEMBL457817 | — | — | 1 | 5.55 |
| CHEMBL458033 | — | — | 1 | 5.46 |
| CHEMBL505436 | — | — | 1 | 5.17 |
| CHEMBL456512 | — | — | 1 | 5.13 |
| CHEMBL335133 | — | — | 1 | 5.10 |
| CHEMBL136933 | EPIPACHYSAMINE D | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL342394 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL464782 | (+)-PACHYSAMINE B | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL455316 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL457817 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL458033 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL505436 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL456512 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL335133 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL136933 | EPIPACHYSAMINE D | IC50 | > | 20000.0 | nM | - |