Assay Detail

CHEMBL1009020

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Functional

Cytotoxicity against camptothecin-resistant human CCRF-CEM cells after 3 days by SRB assay

ChEMBL ↗

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Target

CCRF-CEM (CHEMBL382) ↗

Open DB target context

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CCRF-CEM (CHEMBL382) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target CCRF-CEM

CHEMBL382

Anchored from Assay target.

Protein identity CCRF-CEM

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	CCRF-CEM
Confidence	1 — Organism
Curated By	Autocuration

Target

CCRF-CEM (CHEMBL382) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus.

Arslanian RL, Tang L, Blough S, Ma W, Qiu RG, Katz L, Carney JR.
J Nat Prod (2002) 65 : 1061 -1064
PubMed 12141877 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.89	7.96

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL453818	—	—	1	7.96
CHEMBL96172	EPOTHILONE D	2.0	1	7.82

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL453818	—	IC50	=	11.0	nM	7.96
CHEMBL96172	EPOTHILONE D	IC50	=	15.0	nM	7.82