Assay Detail
Functional
CHEMBL1009225
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B replication in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by tetrazolium-based colorimetric assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and synthesis of 2-(2,6-dibromophenyl)-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 6.53 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL515612 | — | — | 1 | 7.70 |
| CHEMBL475998 | — | — | 1 | 7.40 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.30 |
| CHEMBL514359 | — | — | 1 | 7.22 |
| CHEMBL505569 | — | — | 1 | 7.05 |
| CHEMBL477852 | — | — | 1 | 6.68 |
| CHEMBL509565 | — | — | 1 | 6.66 |
| CHEMBL526304 | — | — | 1 | 6.62 |
| CHEMBL488059 | — | — | 1 | 6.50 |
| CHEMBL53554 | THIAZOLOBENZIMIDAZOLE | — | 1 | 6.46 |
| CHEMBL509783 | — | — | 1 | 6.30 |
| CHEMBL519424 | — | — | 1 | 6.24 |
| CHEMBL296175 | — | — | 1 | 6.22 |
| CHEMBL515176 | — | — | 1 | 6.08 |
| CHEMBL475997 | — | — | 1 | 5.99 |
| CHEMBL477031 | — | — | 1 | 5.34 |
| CHEMBL443380 | — | — | 1 | 5.28 |
| CHEMBL451285 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL515612 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL475998 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL514359 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL505569 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL477852 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL509565 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL526304 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL488059 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL53554 | THIAZOLOBENZIMIDAZOLE | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL509783 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL519424 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL296175 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL515176 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL475997 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL477031 | — | EC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL443380 | — | EC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL451285 | — | EC50 | > | 8650.0 | nM | - |