Assay Detail
Functional
CHEMBL1009696
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reduction in free fatty acid level in 18 hrs fasted po dosed Sprague-Dawley rat
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.76 | 5.30 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573 | NIACIN | 4.0 | 2 | 5.30 |
| CHEMBL482768 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573 | NIACIN | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL482768 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL573 | NIACIN | Activity | - | — | - |