Assay Detail
Binding
CHEMBL1010048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MMP1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.62 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471537 | — | — | 1 | 8.11 |
| CHEMBL514138 | CGS-27023A | — | 1 | 7.25 |
| CHEMBL515980 | — | — | 1 | 7.23 |
| CHEMBL234530 | — | — | 1 | 6.84 |
| CHEMBL450721 | — | — | 1 | 6.63 |
| CHEMBL456774 | — | — | 1 | 6.63 |
| CHEMBL234529 | — | — | 1 | 6.27 |
| CHEMBL234735 | — | — | 1 | 6.27 |
| CHEMBL472899 | — | — | 1 | 5.82 |
| CHEMBL515083 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471537 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 56.3 | nM | 7.25 |
| CHEMBL515980 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL234530 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL450721 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL456774 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL234529 | — | IC50 | = | 532.0 | nM | 6.27 |
| CHEMBL234735 | — | IC50 | = | 542.0 | nM | 6.27 |
| CHEMBL472899 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL515083 | — | IC50 | = | 6770.0 | nM | 5.17 |