Assay Detail
Binding
CHEMBL1010056
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.28 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51668 | — | — | 1 | 7.40 |
| CHEMBL234530 | — | — | 1 | 7.02 |
| CHEMBL388671 | — | — | 1 | 6.94 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL471537 | — | — | 1 | 6.14 |
| CHEMBL234529 | — | — | 1 | 5.75 |
| CHEMBL234737 | — | — | 1 | 5.63 |
| CHEMBL234735 | — | — | 1 | 5.60 |
| CHEMBL388453 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51668 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL234530 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL388671 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL471537 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL234529 | — | Ki | = | 1765.0 | nM | 5.75 |
| CHEMBL234737 | — | Ki | = | 2339.0 | nM | 5.63 |
| CHEMBL234735 | — | Ki | = | 2487.0 | nM | 5.60 |
| CHEMBL388453 | — | Ki | = | 3430.0 | nM | 5.46 |