Assay Detail
Binding
CHEMBL1010087
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum FabH
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Beta-ketoacyl-ACP-synthase III (CHEMBL4968) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.89 | 7.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491752 | — | — | 1 | 7.56 |
| CHEMBL512926 | — | — | 1 | 7.53 |
| CHEMBL455414 | — | — | 1 | 7.33 |
| CHEMBL445555 | — | — | 1 | 7.14 |
| CHEMBL509952 | — | — | 1 | 7.13 |
| CHEMBL460104 | — | — | 1 | 6.89 |
| CHEMBL462205 | — | — | 1 | 6.55 |
| CHEMBL451059 | — | — | 1 | 6.47 |
| CHEMBL462374 | — | — | 1 | 6.41 |
| CHEMBL454282 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491752 | — | IC50 | = | 27.45 | nM | 7.56 |
| CHEMBL512926 | — | IC50 | = | 29.6 | nM | 7.53 |
| CHEMBL455414 | — | IC50 | = | 46.5 | nM | 7.33 |
| CHEMBL445555 | — | IC50 | = | 72.6 | nM | 7.14 |
| CHEMBL509952 | — | IC50 | = | 73.6 | nM | 7.13 |
| CHEMBL460104 | — | IC50 | = | 128.7 | nM | 6.89 |
| CHEMBL462205 | — | IC50 | = | 278.7 | nM | 6.55 |
| CHEMBL451059 | — | IC50 | = | 341.1 | nM | 6.47 |
| CHEMBL462374 | — | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL454282 | — | IC50 | = | 1425.0 | nM | 5.85 |