Assay Detail
Binding
CHEMBL1010125
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Inhibition of human recombinant FGFR1
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 7.38 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL498551 | — | — | 1 | 9.00 |
| CHEMBL495749 | — | — | 1 | 9.00 |
| CHEMBL495762 | — | — | 1 | 8.70 |
| CHEMBL495962 | — | — | 1 | 8.52 |
| CHEMBL495763 | — | — | 1 | 8.52 |
| CHEMBL498013 | — | — | 1 | 8.52 |
| CHEMBL496764 | — | — | 1 | 8.15 |
| CHEMBL495735 | — | — | 1 | 8.10 |
| CHEMBL204427 | — | — | 1 | 8.05 |
| CHEMBL495961 | — | — | 1 | 8.05 |
| CHEMBL498214 | — | — | 1 | 8.00 |
| CHEMBL526507 | — | — | 1 | 8.00 |
| CHEMBL522892 | DOVITINIB | 3.0 | 1 | 7.96 |
| CHEMBL496762 | — | — | 1 | 7.82 |
| CHEMBL496150 | — | — | 1 | 7.70 |
| CHEMBL526658 | — | — | 1 | 7.70 |
| CHEMBL523071 | — | — | 1 | 7.70 |
| CHEMBL523745 | — | — | 1 | 7.62 |
| CHEMBL498347 | — | — | 1 | 7.52 |
| CHEMBL383417 | — | — | 1 | 7.52 |
| CHEMBL204426 | — | — | 1 | 7.52 |
| CHEMBL496763 | — | — | 1 | 7.40 |
| CHEMBL498206 | — | — | 1 | 7.16 |
| CHEMBL498205 | — | — | 1 | 7.10 |
| CHEMBL495529 | — | — | 1 | 7.08 |
| CHEMBL377345 | — | — | 1 | 7.05 |
| CHEMBL522732 | — | — | 1 | 6.96 |
| CHEMBL521552 | — | — | 1 | 6.92 |
| CHEMBL526836 | — | — | 1 | 6.72 |
| CHEMBL495984 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL498551 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL495749 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL495762 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL495962 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL495763 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL498013 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL496764 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL495735 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL204427 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL495961 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL498214 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL526507 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL522892 | DOVITINIB | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL496762 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL523071 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL496150 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL526658 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL523745 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL204426 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL498347 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL383417 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL496763 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL498206 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL498205 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL495529 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL377345 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL522732 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL521552 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL495984 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL526836 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL449593 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL118440 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL495983 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL526285 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL495530 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL498348 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL457985 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL496172 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL523571 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL496173 | — | IC50 | > | 25000.0 | nM | - |