Assay Detail
Binding
CHEMBL1010200
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Inhibition of thrombin
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Modification of the N-terminal sulfonyl residue in 3-amidinophenylalanine-based matriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 6.44 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL516786 | — | — | 1 | 8.00 |
| CHEMBL513818 | — | — | 1 | 7.96 |
| CHEMBL460810 | — | — | 1 | 7.48 |
| CHEMBL460378 | — | — | 1 | 7.40 |
| CHEMBL466588 | — | — | 1 | 7.29 |
| CHEMBL461655 | — | — | 1 | 7.25 |
| CHEMBL461016 | — | — | 1 | 6.96 |
| CHEMBL468895 | — | — | 1 | 6.82 |
| CHEMBL468894 | — | — | 1 | 6.80 |
| CHEMBL499274 | — | — | 1 | 6.72 |
| CHEMBL499200 | — | — | 1 | 6.62 |
| CHEMBL513007 | — | — | 1 | 6.51 |
| CHEMBL518179 | — | — | 1 | 6.35 |
| CHEMBL468270 | — | — | 1 | 6.34 |
| CHEMBL469090 | — | — | 1 | 6.28 |
| CHEMBL453766 | — | — | 1 | 5.96 |
| CHEMBL461441 | — | — | 1 | 5.92 |
| CHEMBL461440 | — | — | 1 | 5.72 |
| CHEMBL512118 | — | — | 1 | 5.66 |
| CHEMBL461870 | — | — | 1 | 5.29 |
| CHEMBL513339 | — | — | 1 | 5.26 |
| CHEMBL466585 | — | — | 1 | 5.01 |
| CHEMBL379194 | — | — | 1 | 4.57 |
| CHEMBL459525 | — | — | 1 | - |
| CHEMBL462253 | — | — | 1 | - |
| CHEMBL514449 | — | — | 1 | - |
| CHEMBL459507 | — | — | 1 | - |
| CHEMBL518010 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL516786 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL513818 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL460810 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL460378 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL466588 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL461655 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL461016 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL468895 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL468894 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL499274 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL499200 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL513007 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL518179 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL468270 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL469090 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL453766 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL461441 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL461440 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL512118 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL461870 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL513339 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL466585 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL379194 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL459525 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL462253 | — | Ki | = | 325000.0 | nM | - |
| CHEMBL514449 | — | Ki | - | — | - | |
| CHEMBL459507 | — | Ki | - | — | - | |
| CHEMBL518010 | — | Ki | - | — | - |