Assay Detail
Functional
CHEMBL1010230
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Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Iron chelators of the dipyridylketone thiosemicarbazone class: precomplexation and transmetalation effects on anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.02 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385064 | — | — | 1 | 8.00 |
| CHEMBL275925 | — | — | 1 | 8.00 |
| CHEMBL413443 | — | — | 1 | 7.30 |
| CHEMBL216895 | — | — | 1 | 7.30 |
| CHEMBL438288 | — | — | 1 | 5.85 |
| CHEMBL385873 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385064 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL275925 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL413443 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL216895 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL438288 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL385873 | — | IC50 | = | 2200.0 | nM | 5.66 |