Assay Detail
Functional
CHEMBL1010302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human progesterone receptor
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A tissue-selective nonsteroidal progesterone receptor modulator: 7,9-difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3,4-f]quinoline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.72 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507701 | — | — | 1 | 9.40 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 9.30 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 9.30 |
| CHEMBL453579 | — | — | 3 | 9.30 |
| CHEMBL510305 | — | — | 1 | 8.47 |
| CHEMBL510373 | — | — | 1 | 8.27 |
| CHEMBL507532 | — | — | 1 | 7.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507701 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL103 | PROGESTERONE | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL453579 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL453579 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL510305 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL510373 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL507532 | — | EC50 | = | 10.7 | nM | 7.97 |
| CHEMBL453579 | — | EC50 | = | 50.8 | nM | 7.29 |