Assay Detail
Binding
CHEMBL1010961
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [D-Trp6]-GnRH from rat recombinant GnRH receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gonadotropin-releasing hormone receptor (CHEMBL3066) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.37 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513998 | — | — | 1 | 7.77 |
| CHEMBL473807 | — | — | 1 | 7.48 |
| CHEMBL459215 | — | — | 1 | 7.40 |
| CHEMBL446978 | — | — | 1 | 7.33 |
| CHEMBL474991 | — | — | 1 | 7.15 |
| CHEMBL475650 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513998 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL473807 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL459215 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL446978 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL474991 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL475650 | — | IC50 | = | 87.0 | nM | 7.06 |