Assay Detail
Binding
CHEMBL1011001
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDGFRbeta
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 8.28 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL526507 | — | — | 1 | 10.00 |
| CHEMBL495749 | — | — | 1 | 10.00 |
| CHEMBL495984 | — | — | 1 | 9.70 |
| CHEMBL495762 | — | — | 1 | 9.52 |
| CHEMBL498551 | — | — | 1 | 9.52 |
| CHEMBL498013 | — | — | 1 | 9.40 |
| CHEMBL495735 | — | — | 1 | 9.22 |
| CHEMBL495763 | — | — | 1 | 9.15 |
| CHEMBL526285 | — | — | 1 | 9.05 |
| CHEMBL498214 | — | — | 1 | 9.05 |
| CHEMBL495962 | — | — | 1 | 9.00 |
| CHEMBL496763 | — | — | 1 | 9.00 |
| CHEMBL204427 | — | — | 1 | 8.70 |
| CHEMBL495961 | — | — | 1 | 8.70 |
| CHEMBL496762 | — | — | 1 | 8.70 |
| CHEMBL522732 | — | — | 1 | 8.52 |
| CHEMBL496150 | — | — | 1 | 8.40 |
| CHEMBL498347 | — | — | 1 | 8.30 |
| CHEMBL522892 | DOVITINIB | 3.0 | 1 | 8.30 |
| CHEMBL523071 | — | — | 1 | 8.30 |
| CHEMBL204426 | — | — | 1 | 8.30 |
| CHEMBL526658 | — | — | 1 | 8.30 |
| CHEMBL496764 | — | — | 1 | 8.15 |
| CHEMBL495529 | — | — | 1 | 8.15 |
| CHEMBL523745 | — | — | 1 | 8.10 |
| CHEMBL449593 | — | — | 1 | 8.05 |
| CHEMBL383417 | — | — | 1 | 8.00 |
| CHEMBL498206 | — | — | 1 | 7.92 |
| CHEMBL526836 | — | — | 1 | 7.85 |
| CHEMBL377345 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL526507 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL495749 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL495984 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL495762 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL498551 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL498013 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL495735 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL495763 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL526285 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL498214 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL495962 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL496763 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL204427 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL495961 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL496762 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL522732 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL496150 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL526658 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL204426 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL522892 | DOVITINIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL498347 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL523071 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL496764 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL495529 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL523745 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL449593 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL383417 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL498206 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL526836 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL377345 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL521552 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL498205 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL498348 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL495530 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL118440 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL495983 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL457985 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL496172 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL523571 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL496173 | — | IC50 | > | 25000.0 | nM | - |