Assay Detail
Functional
CHEMBL1011002
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGF-mediated proliferation of HMVEC after 72 hrs
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HMVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 37 | 7.06 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495763 | — | — | 1 | 8.30 |
| CHEMBL496763 | — | — | 1 | 8.00 |
| CHEMBL495749 | — | — | 1 | 8.00 |
| CHEMBL495762 | — | — | 1 | 7.92 |
| CHEMBL522892 | DOVITINIB | 3.0 | 1 | 7.89 |
| CHEMBL496762 | — | — | 1 | 7.77 |
| CHEMBL496764 | — | — | 1 | 7.77 |
| CHEMBL204427 | — | — | 1 | 7.72 |
| CHEMBL495962 | — | — | 1 | 7.62 |
| CHEMBL523071 | — | — | 1 | 7.60 |
| CHEMBL498013 | — | — | 1 | 7.47 |
| CHEMBL526658 | — | — | 1 | 7.43 |
| CHEMBL523745 | — | — | 1 | 7.41 |
| CHEMBL496150 | — | — | 1 | 7.38 |
| CHEMBL498214 | — | — | 1 | 7.35 |
| CHEMBL204426 | — | — | 1 | 7.29 |
| CHEMBL498205 | — | — | 1 | 7.19 |
| CHEMBL495984 | — | — | 1 | 7.14 |
| CHEMBL383417 | — | — | 1 | 7.11 |
| CHEMBL498347 | — | — | 1 | 7.10 |
| CHEMBL526285 | — | — | 1 | 7.00 |
| CHEMBL526507 | — | — | 1 | 6.92 |
| CHEMBL498206 | — | — | 1 | 6.82 |
| CHEMBL118440 | — | — | 1 | 6.62 |
| CHEMBL449593 | — | — | 1 | 6.57 |
| CHEMBL521552 | — | — | 1 | 6.55 |
| CHEMBL498551 | — | — | 1 | 6.47 |
| CHEMBL526836 | — | — | 1 | 6.38 |
| CHEMBL377345 | — | — | 1 | 6.38 |
| CHEMBL522732 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495763 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL496763 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL495749 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL495762 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL522892 | DOVITINIB | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL496762 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL496764 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL204427 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL495962 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL523071 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL498013 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL526658 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL523745 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL496150 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL498214 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL204426 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL498205 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL495984 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL383417 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL498347 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL526285 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL526507 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL498206 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL118440 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL449593 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL521552 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL498551 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL377345 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL526836 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL522732 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL495735 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL495529 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL498348 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL523571 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL496172 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL496173 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL495983 | — | EC50 | > | 10000.0 | nM | - |