Assay Detail
Binding
CHEMBL1011444
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Inhibition of thrombin
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Cyclotheonamides E2 and E3, new potent serine protease inhibitors from the marine sponge of the genus Theonella.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.02 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507449 | CYCLOTHEONAMIDE E | — | 1 | 8.54 |
| CHEMBL448342 | CYCLOTHEONAMIDE E3 | — | 1 | 8.02 |
| CHEMBL505589 | CYCLOTHEONAMIDE E2 | — | 1 | 7.89 |
| CHEMBL342672 | CYCLOTHEONAMIDE A | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507449 | CYCLOTHEONAMIDE E | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL448342 | CYCLOTHEONAMIDE E3 | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL505589 | CYCLOTHEONAMIDE E2 | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL342672 | CYCLOTHEONAMIDE A | IC50 | = | 23.0 | nM | 7.64 |