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Assay Detail

CHEMBL1011611

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against TbAT1 knock out and pentamidine-resistant Trypanosoma brucei brucei B48 mutant after 48 hrs by alamar blue assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei brucei (CHEMBL612851)
Type ORGANISM
Organism Trypanosoma brucei brucei

Publication

Targeted delivery of compounds to Trypanosoma brucei using the melamine motif.
Chollet C, Baliani A, Wong PE, Barrett MP, Gilbert IH.
Bioorg Med Chem (2009) 17 : 2512 -2523
PubMed 19250832 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.74 5.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL504195 1 5.15
CHEMBL511037 1 4.92
CHEMBL464822 1 4.56
CHEMBL361497 ARTESUNATE 4.0 1 4.56
CHEMBL463820 1 4.50
CHEMBL470813 1 -
CHEMBL470812 1 -
CHEMBL471639 1 -
CHEMBL513766 1 -
CHEMBL1203977 1 -
CHEMBL469968 1 -
CHEMBL517464 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL504195 IC50 = 7100.0 nM 5.15
CHEMBL511037 IC50 = 12100.0 nM 4.92
CHEMBL464822 IC50 = 27700.0 nM 4.56
CHEMBL361497 ARTESUNATE IC50 = 27500.0 nM 4.56
CHEMBL463820 IC50 = 31500.0 nM 4.50
CHEMBL470813 IC50 > 100000.0 nM -
CHEMBL470812 IC50 > 100000.0 nM -
CHEMBL471639 IC50 = 888000.0 nM -
CHEMBL513766 IC50 > 100000.0 nM -
CHEMBL1203977 IC50 > 100000.0 nM -
CHEMBL469968 IC50 > 100000.0 nM -
CHEMBL517464 IC50 > 100000.0 nM -