Assay Detail
Binding
CHEMBL1011746
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Inhibition of JAK2
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Fragment-based discovery of JAK-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.65 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL482189 | — | — | 1 | 7.41 |
| CHEMBL480411 | — | — | 1 | 7.11 |
| CHEMBL510641 | — | — | 1 | 6.50 |
| CHEMBL520947 | — | — | 1 | 6.48 |
| CHEMBL498859 | — | — | 1 | 6.43 |
| CHEMBL481583 | — | — | 1 | 6.13 |
| CHEMBL482188 | — | — | 1 | 6.11 |
| CHEMBL481985 | — | — | 1 | 6.10 |
| CHEMBL479830 | — | — | 1 | 5.96 |
| CHEMBL482187 | — | — | 1 | 5.91 |
| CHEMBL480606 | — | — | 1 | 5.80 |
| CHEMBL500779 | — | — | 1 | 5.80 |
| CHEMBL447670 | — | — | 1 | 5.71 |
| CHEMBL479620 | — | — | 1 | 5.71 |
| CHEMBL480998 | — | — | 1 | 5.45 |
| CHEMBL480412 | — | — | 1 | 5.41 |
| CHEMBL481585 | — | — | 1 | 5.24 |
| CHEMBL519279 | — | — | 1 | 5.07 |
| CHEMBL479619 | — | — | 1 | 5.03 |
| CHEMBL481584 | — | — | 1 | 4.54 |
| CHEMBL465091 | — | — | 1 | 4.39 |
| CHEMBL501406 | — | — | 1 | 3.88 |
| CHEMBL446576 | — | — | 1 | 3.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL482189 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL480411 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL510641 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL520947 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL498859 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL481583 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL482188 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL481985 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL479830 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL482187 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL480606 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL500779 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL447670 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL479620 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL480998 | — | IC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL480412 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL481585 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL519279 | — | IC50 | = | 8580.0 | nM | 5.07 |
| CHEMBL479619 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL481584 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL465091 | — | IC50 | = | 40900.0 | nM | 4.39 |
| CHEMBL501406 | — | IC50 | = | 131000.0 | nM | 3.88 |
| CHEMBL446576 | — | IC50 | = | 145300.0 | nM | 3.84 |