Compound Detail
CHEMBL481985
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Basic Information
| ChEMBL ID | CHEMBL481985 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OBWNDLABSGHHAC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
301.4
MW (Da)
2.61
ALogP
4
HBA
2
HBD
88.8
PSA (Ų)
0.78
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 CHEMBL2971 | IC50 | 6.1 | 6.1 | 790.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 | IC50 | = | 790.0 | nM | 6.1 | Inhibition of JAK2 | 19019674 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19019674 | 10.1016/j.bmcl.2008.08.064 | Tyrosine-protein kinase JAK2 | 1 |
Data from ChEMBL 36 via Core Engine