Assay Detail
Binding
CHEMBL1011817
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Inhibition of nNOS
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.41 | 10.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL474637 | — | — | 1 | 10.07 |
| CHEMBL227937 | — | — | 1 | 9.82 |
| CHEMBL526688 | — | — | 1 | 9.60 |
| CHEMBL44833 | — | — | 1 | 9.52 |
| CHEMBL510760 | — | — | 1 | 9.41 |
| CHEMBL475797 | — | — | 1 | 8.03 |
| CHEMBL228077 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL474637 | — | Ki | = | 0.085 | nM | 10.07 |
| CHEMBL227937 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL526688 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL44833 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL510760 | — | Ki | = | 0.388 | nM | 9.41 |
| CHEMBL475797 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL228077 | — | Ki | = | 0.1 | nM | - |