Assay Detail
Binding
CHEMBL1012730
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Inhibition of human recombinant caspase 3
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fluorinated isatin derivatives. Part 1: synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.80 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216819 | — | — | 1 | 8.62 |
| CHEMBL493926 | — | — | 1 | 8.28 |
| CHEMBL515299 | — | — | 1 | 7.88 |
| CHEMBL494141 | — | — | 1 | 7.60 |
| CHEMBL521840 | — | — | 1 | 7.54 |
| CHEMBL522148 | — | — | 1 | 7.52 |
| CHEMBL494140 | — | — | 1 | 7.39 |
| CHEMBL493127 | — | — | 1 | 7.37 |
| CHEMBL492518 | — | — | 1 | 7.25 |
| CHEMBL483408 | — | — | 1 | 7.18 |
| CHEMBL522324 | — | — | 1 | 7.11 |
| CHEMBL521822 | — | — | 1 | 7.09 |
| CHEMBL493123 | — | — | 1 | 7.08 |
| CHEMBL493927 | — | — | 1 | 7.05 |
| CHEMBL60190 | — | — | 1 | 6.92 |
| CHEMBL521839 | — | — | 1 | 6.74 |
| CHEMBL492322 | — | — | 1 | 6.73 |
| CHEMBL493124 | — | — | 1 | 6.72 |
| CHEMBL475040 | — | — | 1 | 6.67 |
| CHEMBL492718 | — | — | 1 | 6.64 |
| CHEMBL475859 | — | — | 1 | 6.45 |
| CHEMBL524194 | — | — | 1 | 6.30 |
| CHEMBL523710 | — | — | 1 | 5.74 |
| CHEMBL494737 | — | — | 1 | 5.29 |
| CHEMBL494539 | — | — | 1 | 5.22 |
| CHEMBL492936 | — | — | 1 | 5.03 |
| CHEMBL492735 | — | — | 1 | 4.21 |
| CHEMBL475020 | — | — | 1 | - |
| CHEMBL475858 | — | — | 1 | - |
| CHEMBL522191 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216819 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL493926 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL515299 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL494141 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL521840 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL522148 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL494140 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL493127 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL492518 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL483408 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL522324 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL521822 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL493123 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL493927 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL60190 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL521839 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL492322 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL493124 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL475040 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL492718 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL475859 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL524194 | — | IC50 | = | 499.0 | nM | 6.30 |
| CHEMBL523710 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL494737 | — | IC50 | = | 5120.0 | nM | 5.29 |
| CHEMBL494539 | — | IC50 | = | 6080.0 | nM | 5.22 |
| CHEMBL492936 | — | IC50 | = | 9430.0 | nM | 5.03 |
| CHEMBL492735 | — | IC50 | = | 60900.0 | nM | 4.21 |
| CHEMBL475020 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL475858 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL522191 | — | IC50 | > | 100000.0 | nM | - |